August 30th - September 3rd 1997
Ludwig-Maximilians-University Munich
The Scientific Program consists of:
13 Oral Sessions
including two sessions on topic highlights
15 Poster Discussions
2 'Meet the Professor' Sessions
Heart and the Thyroid
Thyroid Hormone Replacement Therapy and TSH Suppression
2 Symposia
Iodine-induced Hyperthyroidism
Evidence-based Thyroidology
2 Workshops
Thyroid-Associated Ophthalmopathy
Role of cell adhesion molecules in diagnosis and prognosis of thyroid diseases
4 Award Lectures
ETA Merck Lecture
ETA Henning Lecture
Lissitzky Prize
ETA Organon M. P. König Poster Award
(Posters will be judged by members of the Executive Committee in terms
of scientific quality and presentation; the recipient of this award will
be invited to present a synopsis of the poster.)
All abstracts of the Scientific Program
are available on floppy disk (courtesy of Berlin-Chemie AG). ETA members
will have received a disk prior to the meeting. A limited number of floppy
disks is available at the registration desk free of charge for congress
participants who are not ETA members.
Saturday, August 30th
"Lichthof" - Main Entrance Hall
18:00 Get together Party
All registered participants and accompanying persons are invited
to attend the welcome party.
19:00 - 19:15 Opening Ceremony
All participants and accompanying persons are invited to attend
the official opening ceremony.
Welcome
Klaus Peter, Dean of the Medical Faculty of the Ludwig-Maximilians-University
Peter C. Scriba, Honorary President of the Local Organizing Committee
Roland Gärtner, President
Opening address
Jacques E. Dumont President of the European Thyroid Association
Sunday, August 31st
"Auditorium Maximum"
08:30 - 10:30 Oral Session 1: Topic Highlights
I
Chair: Jacques F. Dumont, Brussels
Co-chair: Hans A. Gerber, Bern
08:30 1. Disruption of the TTF-2 gene by homologous recombination shows
its essential role in thyroid morphogenesis
Rodriguez Mallon, A.; De Felice, M.; Ovitt, C.; Mariano, A.; Biffali, E.;
Macchia, V.; Schöler, H.; Di Lauro, R. (Naples, Heidelberg)
08:50 2. PAX-8 can reactivate the entire differentiated program in thyroid
cells transformed by polyoma middle T. Pasca, M.; Zannini, M. (Naples)
09:10 3. Study of interaction between the extracellular and transmembrane
domains of the TSH-receptor with receptor chimeras
Rodien, P.; Cetani, F.; Costagliola, S.; Vassart, G. (Brussels)
09:30 4. Production of monoclonal antibodies recognizing the native
human TSH-R and induction of thyroiditis in Balb/c mice by genetic immunization
Costagliola, S.; Vassart, G. (Brussels)
09:50 5. Endothelium-dependent vasodilatation is impaired in hypothyroidism,
borderline hypothyroidism and in persons with TSH levels considered "high-normal"
Alevizaki, M.; Lekakis, J.; Papamichael, C.; Piperingos, G.; Marafellia,
P.; Mantzos, J.; Stamatelopoulos, S.; Koutras, D. A. (Athens)
10:10 6. Day-time and night-time serum TSH isoforms have different glycosylation
and bioactivity
Persani, L.; Borgato, S.; Pizzocaro, A.; Grugni, G.; Faglia, G.; Beck-Peccoz,
P. (Milan)
10:30 - 11:00 Coffee break
Sunday, August 31st
"Auditorium Maximum"
11:00 - 13:00 Oral Session 2: TSH and TSH Receptors,
Thyroid Cancer
Chair: Gilbert Vassart, Brussels
Co-chair: Annette Grüters-Kieslich, Berlin
11:00 7. Elevated incidence of TSH-R gene mutations in toxic adenoma
and in hot nodules of toxic multinodular goiters
Tonacchera, M.; Chiovato, L.; Fiore, E.; Agretti, P.; Cetani, F.; Rocchi,
R.; Ceccarini, G.; Cavaliere, R.; Miccoli, P.; Pinchera, A.; Vitti, P.
(Pisa)
11:15 8. Somatic mutations in the thyrotropin receptor gene and not
in the Gs alpha protein gene in 34 toxic thyroid nodules
Führer, D.; Wonerow, P.; Holzapfel, H.-P. (Leipzig)
11:30 9. Deletions in the third cytoplasmatic loop of the thyrotropin
receptor represent a new mechanism for constitutive activation
Wonerow, P.; Schöneberg, T.; Gudermann, T.; Paschke, R. (Leipzig,
Berlin)
11:45 10. Comparison of the effect of gsp and activating mutations of
the thyrotropin receptor (TSH-R) on thyroid cells using retroviral vectors
Ludgate, M.; Gire, V.; Crisp, M.; Ivan, M. (Cardiff)
12:00 11. Functional properties of new TSH-R mutations
Fiore, E.; Tonacchera, M.; Agretti, P.; Mammoli, C.; Giulianetti, B.; Ceccarini,
G.; Mazzi, B.; Vitti, P.; Chiovato, L. (Pisa)
12:15 12. TSH (PKA) inhibits phorbol ester (PKC)-induced c-jun and c-fos
gene expression in non-neoplastic and follicular, but not papillary, human
thyroid cells, in contrast to such EGF-induced gene expression which was
inhibited by TSH (PKA) in non neoplastic but not follicular or papillary
human thyrocytes
Kraiem, Z.; Heinrich, R.; Sadeh, O.; Gorenstein, G.; Sasson, R. (Haifa)
12:30 13. Activation of mitogen-activated protein kinase (MAPK) in human
primary thyroid epithelial cells by oncogenic p21 RAS protein
Gire, V.; Marshall, C. J.; Wynford-Thomas, D. (Cardiff, London)
12:45 14. Protein tyrosine phosphatase inhibitors induce tyrosine phosphorylation
of the thyroid junction complex and loss of epithelial barrier function
Nilsson, M.; Khatibi, N.; Fassoulas, A.; Husmark, J. (Göteborg)
13:00 - 14:30 Lunch and Poster display
Sunday, August 31st
Lecture Room 116
13:15 - 14:30 Meet the Professor: Heart and the
Thyroid
Albert Burger, Geneva
Lecture Room 117
13:15 -14:30 Meet the Professor: Thyroid Hormone
Replacement Therapy and TSH Suppression
Aldo Pinchera, Tirrenia-Pisa
Sunday, August 31st
"Auditorium Maximum"
14:30 - 15:30 Oral Session 3: Clinical Disturbances
of Thyroid Function
Chair: Janusz A. Nauman, Warsaw
Co-chair: Enio Martino, Tirrenia-Pisa
14:30 15. Bone mass (BMD) after radioiodine treatment of postmenopausal
women with multinodular goiter and subclinical hyperthyroidism
Faber, J.; Nygaard, B.; Jensen, I.; Siersbæk-Nielsen, K. (Frederiksberg)
14:45 16. A prospective randomized trial comparing suppressive doses
of L-thyroxine with percutaneous ethanol injection therapy in solitary
solid cold benign thyroid nodules
Bennedbæk, F. N.; Nielsen, L. K.; Hegedüs, L. (Odense)
15:00 17. Increased thyroid volume and prevalence of thyroid antibodies
in the area heavily polluted by polychlorinated biphenyls
Langer, P.; Tajtáková, M; Hanzen, E.; Fodor, G.; Bohov, P.;
Michálek, J. (Bratislava, Ko_ice, Lubochna)
15:15 18. The association of radioiodine (RI) with lithium carbonate
allows a more effective and prompter control of Graves" hyperthyroidism
than RI alone
Bogazzi, F.; Bartalena, L; Brogioni, S.; Scarcello, G.; Burelli, A.; Campomori,
A.; Manetti, L.; Dell'Unto, E.; Martino, E. (Tirrenia - Pisa)
15:30 - 16:00 Coffee break
Sunday, August 31st
"Kleine Aula" - Lecture Room 209
14:30 - 15:30 Oral Session 4: Thyroid Cancer
Chair: Alfredo Fusco, Cantanzano
Co-chair: David Wynford-Thomas, Cardiff
14:30 19. CD97: A dedifferentiation marker in human thyroid carcinomas
Aust, G.; Eichler, W.; Laue, S.; Lehmann, I.; Lotz, O.; Scherbaum, W. A.;
Dralle, H.; Hoang-Vu, C. (Leipzig, Halle - Wittenberg)
14:45 20. Functional dissection of thyroid neoplastic progression: An
adhesion-based multi-step carcinogenesis
De Filippi, R.; Trusolino, L.; Serini, G.; Ciarfaglia, F.; Cecchini, G.;
Besati, C.; Marchisio, P. C.; Ambesi-Impiombato, F. S. (Udine, Milan, Torino)
15:00 21. Effect of doxorubicin, cisplatin and camptothecin on apoptosis
and expression of apoptosis-related proteins in thyroid tumor cells and
its clinical relevance
de Buhr, I.; Bröcker, M.; Harrer, P.; Zumtobel, V.; Schatz, H.; Derwahl,
M. (Bochum)
15:15 22. Decreased levels of retinoid x receptor beta (RXRb) mRNA in
human thyroid carcinomas
Winzer, R.; Simon, D.; Goretzki, P. E.; Schmutzler, C. (Würzburg,
Düsseldorf)
15:30 - 16:00 Coffee break
Sunday, August 31st
"Auditorium Maximum"
16:00 -18:00 Oral Session 5: Thyroid Hormone Action
Chair: Daan van der Heide, Wageningen
Co-chair: Harald Meinhold, Berlin
16:0 23. Effects of disturbances of thyroid function on various entities
of the serotonergic system in the rat
Koulikov, A.; Jeanningros, R. (Marseille)
16:15 24. Decreased thyrotropin-releasing hormone (TRH) gene expression
in the paraventricular nucleus of patients with nonthyroidal illness
Fliers, E.; Guldenaar, S. E. F.; Wiersinga, W. M.; Swaab, D. F. (Amsterdam)
16:3 25. Ligand-dependent transcriptional interference between vitamin
D3 and thyroid hormone receptors by competing common cofactor(s)
Nakamura, H.; Natsume, H.; Andoh, S.; Kitahara, A.; Mikami, T.; Gemma,
R.; Nishiyama, K. (Hamamatsu)
16:45 26. T3 enhances heterodimer formation between thyroid hormone
receptor b and retinoid x receptor
Collingwood, T. N.; Butler, A.; Tone, Y.; Clifton-Bligh, R. J.; Parker,
M. G.; Chatterjee, V. K. K. (Cambridge, London)
17:00 27. Hypothyroidism causes specific alterations in the expression
of prostaglandin D2 synthase and tenascin-C during rat brain development
Muñoz, A.; GarcÌa-Fernández, L. F.; Alvarez-Dolado,
M.; Rausell, E; Urade, Y.; Hayaishi, O.; Bernal, J. (Madrid, Osaka)
17:15 28. Regional expression of 5"-deiodinase II in the rat brain
as studied by in situ hybridization
Guadaño-Ferraz, A.; Bernal, J. (Madrid)
17:30 29. Positive and negative regulatory sequence elements modulate
retinoic acid responsivity of the human type I 5´-deiodinase promoter
Schmutzler, C.; Jakobs, T. C.; Köhrle, J. (Würzburg)
17:45 30. Changes in serum leptin levels do not correlate to total fat
mass in patient with thyrotoxicosis
Zimmermann-Belsing, T.; Dreyer, M.; Juul-Holst, J.; Feldt-Rasmussen, U.
(Copenhagen)
19:00 - 21:00 Municipal Welcome Reception,
Old City Hall, Marienplatz
Sunday, August 31st
"Kleine Aula" - Lecture Room 209
16:00 -18:00 Oral Session 6: Thyroid Cancer
Chair: Furio Pacini, Pisa
Co-chair: Peter E. Goretzki, Düsseldorf
16:00 31. Solitary, multiple and familial oxyphil tumours of the thyroid
Katoh, R.; Harach, H. R.; Williams, E. D. (Cambridge, Yamanashi)
16:15 32. Prognostic significance of tumor-associated macrophages in
papillary thyroid cancer
Belfiore, A.; Fiumara, A.; Gangemi, P.; Russo, G.; Salomone, E.; Santonocito,
G. M.; Vigneri, R. (Catania)
16:30 33. Expression of HGF and HGF-receptor (c-met) in the papillary
thyroid cancer (PTC)
Trovato, M.; Villari, D.; Bartolone, L.; Spinella, S.; Violi, M. A.; Trimarchi,
F.; Batolo, D.; Benvenga, S. (Messina)
16:45 34. Improved detection and therapy of occult and metastatic medullary
thyroid cancer with radiolabeled anti-carcinoembryonic antigen antibodies
and peptides
Behr, T. M.; Juweid, M. E.; Gratz, S.; Goldenberg, D. M.; Becker, W. (Göttingen,
Belleville)
17:00 35. The use of recombinant human TSH in the detection of well-
differentiated thyroid cancer by 131I imaging and thyroglobulin testing
Pacini, F.; Reiners, C.; Schlumberger, M.; Incerti, C. (Cisanello - Pisa)
17:15 36. 129I, a long-lived indicator of thyroid contamination from
the Chernobyl reactor accident
VanMiddlesworth, L.; Handl, J. (Memphis, Hannover)
17:30 37. C cell hyperplasia (CCH) revisited in presymptomatic inherited
MTC
Franc, B.; Labat-Moleur, F.; Caillou, B.; Houcke-Lecomte, M.; Le Bodic,
M. F.; Patey, M.; Dutrieux-Berger, N.; Saint-André, J. P. (Boulogne
Billancourt, Grenoble, Lille, Nantes, Reims, Lyon, Angers)
17:45 38. Increased risk of thyroid cancer among Norwegian women married
to fishery workers
Frich, L.; Akslen, L. A.; Glattre, E. (Oslo, Bergen)
19:00 - 21:00 Municipal Welcome Reception,
Old City Hall, Marienplatz
Monday, September 1st
"Auditorium Maximum"
08:15 - 09:00 ETA Merck Lecture
09:00 - 10:30 Oral Session 7: Thyroid Cell Biology
Chair: Pierre P. Roger, Brussels
Co-chair: Andrzej Lewinski, Lodz
09:00 39. Melatonin is an anti-goitrogen for the NaClO4 induced goitre
in the rat
Gaspár, E.; Wenzel, K.-W.; Felszeghy, K.; Wenzel, B. E. (Lübeck,
Budapest)
09:15 40. Enzymatic activity and intracellular trafficking of TPO2 expressed
in CHO cells
Niccoli, P.; Fayadat, L.; Panneels, V.; Lanet, J.; Franc, J. L. (Marseille,
Brussels)
09:30 41. New insight into the proliferation potential of thyroid cells
in vitro. Evidence that pig thyrocytes have the capacity of fifteen population
doublings
Statuto, M.; Audebet, C.; Munari-Silem, Y.; Ruby-Selmi, S.; Rousset, B.
(Lyon)
09:45 42. Hexamethylenebisacetamide induces follicle formation, prevents
the loss in cell-TSH sensitivity but inhibits iodide metabolism and decreases
cell protein levels in porcine thyroid cells
Amphoux-Fazekas, T.; Fayet, G.; Hovsépian, S.; Aouani, A.; Samih,
N. (Marseille)
10:00 43. Involvement of integrins and the fibrinolytic system in matrix
degradation by metastatic follicular thyroid carcinoma cell-lines
Smit, J. W. A.; VanderPluijm, G.; Vloedgraven, H. J. M.; Löwik, C.
W. G. M.; Goslings, B. M. (Leiden)
10:15 44. Iodoamino acid composition and iodide release by oxidative
reaction assign a role for compacted thyroglobulin in iodine storage
Baudry, N.; Lejeune, P. J.; Vinet, L.; Carayon, P.; Mallet, B. (Marseille)
10:30 - 11:00 Coffee break
Monday, September 1st
"Auditorium Maximum"
11:00 - 13:05 Oral Session 8: Autoimmunity
Chair: Dolores Schendel, Munich
Co-chair: Ulla Feldt-Rasmussen, Copenhagen
11:00 Introduction
D. Schendel, Munich
11:20 45. Natural processing of the autoantigen thyroid peroxidase in
the endosomal compartments of antigen presenting cells; in vivo and in
vitro studies
Banga, J. P.; Gardas, A.; Verwoerd, D.; McGregor, A. M.; Neefjes, J.; Tulp,
A. (London, Warsaw, Amsterdam)
11:35 46. HLA DRa gene expression in thyrocytes: Regulation by gIFN
and CIITA transactivator
Montani, V.; Taniguchi, S.; Giuliani, C.; Napolitano, G.; Ohmori, M.; Singer,
D.; Monaco, F.; Kohn, L. D. (Chieti)
11:50 47. Increased frequency of humoral thyroid autoimmunity in Belarus
children and adolescents post-Chernobyl accident
Molinaro, E.; Pacini, F.; Agate, L.; Vorontsova, T.; Marinò; M.;
Elisei, R.; Romei, C.; Lippi, F.; Shavrova, E.; Demidchik, E.; Pinchera,
A. (Cisanello - Pisa, Minsk)
12:05 48. Genetics versus environment in Graves" disease - a population
based study of Danish twins
Brix, T. H.; Christensen, K.; Holm, N. V.; Harvald, B.; Hauge, M.; Hegedüs,
L. (Odense)
12:20 49. Induction of the organ specific immune response by homing
of Graves" disease lymphocytes into xenotransplanted thyroid tissue
Jungheim, K.; Usadel, K. H.; Caspar, G.; Hermann, G.; Fortmeyer, H. P.;
Schumm-Draeger, P. M. (Frankfurt/Main)
12:35 50. A CTLA4 promoter polymorphism is associated with Hashimoto"s
thyroiditis
Braun; J.; Donner, H.; Badenhoop, K. (Frankfurt/Main)
12:50 51. Interferon alpha prevents the iodine-induced destruction of
thyroid follicles in non obese diabetic (NOD) mice, but favours the production
of antithyroid autoantibodies
Many, M.-C.; Carpentier, S.; Coetsier, C.; Bizimungu, D.; Germeau, C.;
Dardenne, M.; Drexhage, H. A.; Denef, J.-F. (Brussels, Paris, Rotterdam)
13:05 - 15:30 Lunch and Poster display
Monday, September 1st
Lecture Room 118
13:30 - 15:30 Workshop: Thyroid-Associated Ophthalmopathy:
What we do and what we should be doing Chair: Wilmar M. Wiersinga,
Amsterdam
13:30 - 13:55 "What we do": results of a European survey
A. P. Weetman, Sheffield
13:55 - 14:00 Discussion
14:00 - 14:25 "What we should be doing": comments on medical
management
A. E. Heufelder, Munich
14:25 - 14:50 "What we should be doing": comments on surgical
management
L. Tallstedt, Stockholm
14:50 - 15:10 "What we do" as perceived by the patient
C. B. Terwee, Amsterdam
15:10 - 15:30 General Discussion
Monday, September 1st
Lecture Room 215
13:30 - 15:30 Workshop: Role of cell adhesion
molecules in diagnosis and prognosis of thyroid diseases
Chair: Lucio Nitsch, Naples
Co-chair: Georg Brabant, Hannover
13:30 - 13:35 Introduction
L. Nitsch, Naples
13:35 - 14:00 Genetics of b1 integrin function
R. Fässler, Martinsried
14:00 - 14:20 Altered integrin expression in thyroid diseases
M. Vitale, Naples
14:20 - 14:45 Cadherins and catenins in signal transduction and tumor
progression
J. Behrens, Berlin
14:45 - 15:05 The cadherin-catenin complex in the thyroid epithelium:
implications for subtyping and prognosis of thyroid cancer
M. Nilsson, Göteborg
15:05 - 15:25 Are connexins potential markers of thyroid tumors?
B. Rousset, Lyon
15:25 - 15:30 General discussion and concluding remarks
G. Brabant, Hannover
Monday, September 1st
"Auditorium Maximum"
15:30 - 16:15 Oral Session 9: TSH and TSH Receptors
Chair: Marian E. Ludgate, Cardiff
Co-chair: Ralf Paschke, Leipzig
15:30 52. Analysis of carbohydrate residues on human recombinant TSH
receptor
Sanders, J. F.; Roberts, S.; Oda, Y.; Maruyama, M.; Furmaniak, J.; Rees
Smith, B. (Cardiff)
15:45 53. Regulation of the rat thyrotropin receptor gene by methylation
sensitive transcription factor GA-binding protein
Yokomori; N.; Tawata, M.; Shimura, H.; Saito, T.; Onaya, T. (Yamanshi)
16:00 54. Human anterior pituitary contains a TSH-receptor
Prummel, M. F.; Méduri, G.; Loosfelt, H. (Amsterdam, Paris)
16:15 Excursion, Lake "Starnberg"
Tuesday, September 2nd
"Auditorium Maximum"
08:15 09:00 ETA Henning Lecture
09:00 - 10:30 Oral Session 10: Clinical Disturbances
of Thyroid Function
Chair: Jacques J. Orgiazzi, Lyon
Co-Chair: Reinhard Finke, Berlin
09:00 55. Intramuscular slow-release lanreotide treatment in patients
with TSH-secreting pituitary adenomas
Caron, P.; Beck-Peccoz, P.; Dewailly, D.; Archambaud, F.; Chanson, P.;
Goth, M. I.; Tabarin, A.; Ispas, S.; Blumberg, J.; Kuhn, J. M. (Toulouse,
Milan, Lille, Limoges, Kremlin-Bicêtre, Budapest, Bordeaux, Rouen,
Paris)
09:15 56. Carnitine (C) as a peripheral antagonist of thyroid hormones
(TH): A clinical trial
Benvenga, S.; Bartolone, L.; Russo, A.; Aricò, N. C.; Trimarchi,
F. (Messina)
09:30 57. Increased oxidizability of low density lipoproteins in hypothyroidism
Diekmann, M. J. M.; Vogelaar, J.; Kastelein, J. J. P.; Stalenhoef, A. F.
H.; Demacker, P. N. M.; Wiersinga, W. M. (Amsterdam, Nijmegen)
09:45 58. Evidence for thyrotropin receptor antibodies, which are not
TSH agonists/antagonists, in thyroid associated ophthalmopathy (TAO)
Crisp, M.S.; Weetman, A. P.; Ludgate, M. E. (Cardiff, Sheffield)
10:00 59. Chronic fibrosclerosing pancreatitis associated with Riedel"s
struma: A potentially steroid-responsive disease
Natt, N.; Sharma, V. K.; Arora, A. S.; Goellner, J. R.; Batts, K. P.; Wheeler,
M. H.; Hay, I. D. (Rochester, Cardiff)
10:15 60. To measure or not to measure both urinary creatinine and volume
in the assessment of ioduria? That is the question
Als, C.; Minder, C.; Willems, D.; Van Thi, H. V.; Gerber, H.; Bourdoux,
P. (Bern, Brussels)
10:30 - 11:00 Coffee break
Tuesday, September 2nd
"Auditorium Maximum"
11:00 - 13:05 Oral Session 11: Thyroid Hormone
Metabolism
Chair: Theo J. Visser, Rotterdam
Co-chair: Maria J. Obregon, Madrid
11:00 61. Effects of moderate (MID) and severe iodine deficiency (LID)
on iodothyronine deiodinase type I, II and III (D1, D2, D3) activities
in fetal tissues
Schröder-van der Elst, J. P.; Obregon, M. J. van der Heide, D.; Huijsmans,
Z. A. A.; van Nuenen, H. M. C. (Madrid, Wageningen)
11:20 62. Are iodine-deficient rats euthyroid?
Pedraza, P. E.; Escobar del Rey, F.; Morreale de Escobar, G. (Madrid)
11:35 63. The role of thyroid hormone sulfation during fetal development
Kester, M. H. A.; Tibboel, D.; Visser, T. J. (Rotterdam)
11:50 64. Comparison of [125I]T3 and [125I]triac uptake in neonatal
rat cardiomyocytes
Verhoeven, F. A.; Hennemann, G.; Everts, M. E. (Utrecht, Rotterdam)
12:05 65. Expression of the type II iodothyronine deiodinase selenoprotein
in cultured rat astrocytes
Pallud, S.; Lennon, A. M.; Ramaugé, M.; Gavaret, J. M.; Croteau,
W.; Pierre, M.; Courtin, F.; St Germain, D. L. (Kremlin-Bicêtre,
Lebanon)
12:20 66. A PCR-based strategy for the characterization of the human
type II 5" deiodinase gene
Celi, F. S.; Cannettieri, G.; Andreoli, M.; Shuldiner, A. R.; Centanni,
M. (Rome, Baltimore)
12:35 67. Role of "ERK cascade" in regulation of DIII deiodinase
in cultured rat astrocytes
Courtin, F.; Pallud, S.; Lennon, A. M.; Croteau, W.; Ramaugé, M.;
Gavaret, J. M.; St Germain, D. L.; Pierre, M. (Kremlin-Bicêtre, Lebanon)
12:50 68. Transport of T4-sulfamate (T4NS) and T3NS into Xenopus laevis
oocytes induced by injection of rat liver mRNA
Friesema, E. C. H.; Moerings, E. P. C. M.; Hennemann, G.; Visser, T. J.;
Docter, R. (Rotterdam)
13:05 -15:00 Lunch and Poster display
Tuesday, September 2nd
"Kleine Aula" - Lecture Room 209
13:15 - 15:00 Clinical Symposium: Iodine-induced
Hyperthyroidism
Chair: André M. Ermans, Brussels
Introduction
A. M. Ermans, Brussels
Amiodarone-induced hyperthyroidism
E. Martino, Tirrenia-Pisa
Hyperthyroidism induced by incidental iodine contamination and X rays
iodinated agents
P. Laurberg, Aalborg
Hyperthyroidism induced by excessive iodine supplementation in iodine
deficient populations
A. M. Ermans, Brussels
Molecular basis of thyroid autonomy
J. E. Dumont, Brussels
Tuesday, September 2nd
Lecture Room 116
15:00 - 16:00 Poster discussion 1: Autoimmunity
Discussion Leader: Klaus Badenhoop, Frankfurt/Main
69. CTLA4 promoter variants in patients with Graves' disease
Donner, H.; Braun, J.; Badenhoop, K. (Frankfurt)
70. Polymorphisms in the CTLA-4 Gene are associated with postpartum
thyroiditis (PPT)
Waterman, E. A.; Kotsa, K.; Watson, P. F.; Lazarus, J. H.; Parkes, A. B.;
Darke, C.; Weetman, A. P. (Sheffield, Cardiff)
71. Interferon-gamma polymorphism in Graves' disease
Siegmund, T.; Usadel, K.-H. (Frankfurt)
72. Lack of association of Graves' disease with the A2-allele of the
interleukin-1 receptor antagonist gene in an European Caucasian population
Mühlberg, T.; Kirchberger, M.; Spitzweg, C.; Herrmann, F.; Joba, W.;
Heberling, H.-J.; Heufelder, A. E. (Leipzig, Munich)
73. Thyroid autoimmunity in pregnant women at increased risk for gestational
diabetes mellitus (GDM)
Olivieri, A.; Magnani, F.; Valensise, H.; Archivio, M. D.; Medda, E.; Sorcini,
M.; Baccarini, S.; Romanini, C.; Carta, S. (Roma)
74. Analysis of thyroid autoantibodies and lymphocyte subsets in girls
with hyperthyroidism
Ben-Skowronek, I.; Walter-Croneck, B.; Szewczyk, L. (Lublin)
75. Thyroid and islet cell autoantibodies in school children: influence
of sex and age
Mariotti, S.; Cambosu, M. A.; Loviselli, A.; Velluzzi, F.; Mele, P.; Mossa,
P.; Atzeni, F.; Balestrieri, A.; Schattock, M.; Bottazzo, G. F. (Cagliari,
London)
76. Unilateral autoimmune thyroid disease in a 31 year old female patient:
a case report
Dimai, H. P.; Ramschak-Schwartzer, S.; Lax, S.; Lipp, R.; Leb, G. (Graz)
77. Transmission of auto-immune thyroid diseases in multiplex families:
preliminary clinical data
Beressi, J. P.; Toubert, M. E.; Tournier-Lasserve, E.; Maugendre, D.; Wemeau,
J. L..; Archambeaud-Mouveroux, F.; Cohen, R.; Ghaly, I.; Bakiri, F.; Misrahi,
M.; Lathrop, M.; Vexiau, P. (Paris, Lille, Bobigny, Cairo, Algiers, Kremlin-
Bicêtre, Oxford)
78. Surgery for Graves' disease (super-subtotal thyroidectomy to prevent
relapse after surgery)
Kurihara, H.; Tanimura, S.; Sasaki, J. (Morioka)
16:00 - 16:30 Coffee break
Tuesday, September 2nd
Lecture Room 117
15:00 - 16:00 Poster discussion 2: Clinical Disturbances
of Thyroid Function
Discussion Leader: Daniel Glinoer, Brussels
79. Occupational exposure to radiation may be a risk factor for thyroid
nodules in subjects with a direct exposure to X-ray
Antonelli, A.; Silvano, G.; Gambuzza, C.; Bianchi, F.; Tana, L.; Fallahi,
P.; Baschieri, L. (Pisa)
80. Increasing iodine excess due to industrialized food production
Riccabona, G.; Moncayo, R.; Artner-Dworzak, E.; Bacher-Stier, C. (Innsbruck)
81. The prevalence of thyroid structural abnormalities and a two- years
follow-up on solitary nodules in a random sample from a population with
borderline iodine deficiency
Knudsen, N.; Perrild, H.; Jørgensen, T.; Christiansen, E.; Rasmussen,
S.; Dige-Petersen, H. (Copenhagen)
82. Prevalance of thyroid disorders in Lithuania
_idlauskas, V.; Krasauskiene, A.; Jakuboniene, N.; Auk_tuolyte, A.; Ma_anauskaite,
D.; Telksnys, A. (Kaunas)
83. Thyroid volume in children
Vulpoi,C.; Zbranca, E.; Preda, C.; Ungureanu, C.; Constantinescu, G.; Toma,
C.; Bredetean, O.; Cojocaru, M. (Iasi)
84. Thyroid volume in pregnant women
Mogos, V.; Nicolau, C.; Dumitrache, F.; Pricop, F.; Georgescu, G. (Iasi)
85. Diagnosis of chronic thyroiditis by sonography and fine-needle aspiration
cytology
Andreoli, M.; Bocale, R.; Messina, G.; Danese, D.; Trinti, B.; Pontecorvi,
A. (Rome)
86. Percutaneus ethanol injection in autonomously functioning thyroid
nodules
Zbranca, E.; Vulpoi, C.; Mogos, V.; Rusu, V.; Ungureanu, C.; Toma, C.;
Rusu, M.; Apostu, L. (Iasi)
16:00 - 16:30 Coffee break
Tuesday, September 2nd
Lecture Room 118
15:00 -16:00 Poster discussion 3: Iodine Metabolism
Discussion Leader: Hans Bürgi, Solothurn
87. A negative iodine balance is found in healthy neonates compared
to neonates with thyroid agenesis
Bakker, B.; Vulsma, T.; de Randamie, J.; Achterhuis, A. M.; Oosting, H.;
de Vijlder, J. J. M. (Amsterdam)
88. Iodine deficiency disorders and congenital hypothyrodism in western
Siberia
Suplotova, L. A.; Nekrasova, M. R.; Gubina, V. V.; Luzina, I. G.; Karnauhova,
U. B.; Bojarinova, I. B. (Tyumen)
89. Effect of preparation of iodized oil (lipiodol) on activity of peroxide
oxydation of lipids, antioxidant functions and structural-functional peculiarities
of membranes in erythrocytes for children with endemic goiter
Karnauhova, U.B.; Suplotova, L. A.; Osadtchenko, G. A. (Tyumen)
90. Programs of iodine supplementation: a worldwide evaluation of salt
iodization
Bourdoux, P.; Van Thi, H. V.; Van Stichelen, S.; Ermans, A. M. (Brussels)
91. The effectiveness of different methods of iodine supplementation
in children from the region with mild and moderate iodine deficiency (IDD)
Sviridenko, N.; Schischkina, A.; Mayorova, N. (Moscow)
92. Prevalence of thyroid diseases in a slight endemic area: a randomized
study
Fallahi, P.; Antonelli, A.; Miccoli, P.; Cristofani, R.; Ferdeghini, M.;
Baschieri, L. (Pisa)
93. Present situation of endemic goiter in an area near Tarragona (NE
Spain)
Simón, I.; Simón, C. I.; Olona, M.; Simón, O.; Gutiérrez,
C.; Vendrell, J.; Broch, M.; Pastor, R.; Pujol, A.; Richart, C. (Tarragona,
Barcelona)
94. Prevalence of goiter, thyroid volume and urinary iodine excretion
among schoolchildren in Lithuania
Krasauskiene, A.; _idlauskas, V.; Kadziauskiene, K.; Bartkeviclute, R.;
Berontiene, R. (Kaunas)
95. Effect of oral iodized oil (Io) on indices of autoimmune thyroiditis
in children living in a moderate iodine deficiency area
Simescu, M.; Virciu, M.; Podoba, J.; Gnat, D.; Nicolaescu, E.; Avram, A.;
Mihaescu, M.; Costache, C. (Bucharest, Brasov, Brussels, Bratislava)
96. Subclinical hypothyroidism: Clinical entity or not?
Papadam, A.J.; Karalis, D.; Vogiatzakis, D.; Alevra, A.; Augoustis, C.;
Palouka, T.; Karageorgos, G.; Drouka, V.; Papastergiou, K.; Lakka, E. (Athens)
16:00 - 16:30 Coffee break
Tuesday, September 2nd
Lecture Room 214
15:00 - 16:00 Poster discussion 4: Thyroid Cell
Biology
Discussion Leader: Roberto Di Lauro, Naples
97. Dissociation of telomere dynamics from telomerase activity in human
thyroid cancer cells
Jones, C. J.; Soley, A.; Gupta, J.; Haughton, M.; Wyllie, F.; Bacchetti,
S.; Wynford-Thomas, D. (Cardiff, Hamilton)
98. The transcription factor CREB is phosphorylated in response to activation
of protein kinase A- and tyrosine kinase-dependent pathways in FRTL5 and
thyroid carcinoma cells
Bröcker, M.; Sobke, A.; Derwahl, M. (Bochum)
99. Differential regulation of the HGF-receptor (c-met) mRNA in human
thyroid cells
Schulte, K. M.; Ellrichmann, M.; Antoch, G.; Goretzki, P. E.; Röher,
H.-D. (Düsseldorf)
100. Urokinase-type plasminogen activator receptor in human thyroid
cells
Ragno, P.; Covelli, B.; Montuori, N. (Naples)
101. Nuclear localization of epidermal growth factor and its receptor
in human thyroid tissue: a new site of action?
Marti, U.; Ruchti, C.; Kämpf, J.; Bürgi, U.; Peter, H. J.; Gerber,
H. (Bern)
102. Expression of basic fibroblast growth factor mRNA and its regulation
by TSH, iodine and other growth factors in isolated porcine thyroid follicles
Schäfer, S.; Schopohl, D.; Rank, P.; Sachse, A.; Gärtner, R.
(Munich)
103. Identification and characterization of retinoid-response genes
in porcine thyrocytes by differential display reverse transcription polymerase
chain reaction (DDRT-PCR)
Witke, A.; Koch, M.; Wahl, R. (Tübingen)
104. Expression of the asialoglycoprotein receptor (ASGPr) in rat thyroid
Pacifico, F. M.; Liguoro, D.; Ulianich, L.; Acquaviva, R.; Marinaccio,
M.; Di Jeso, B.; Formisano, S.; Consiglio, E. (Naples)
105. Altered signal transduction pathways in thyroid exerted by TSH
and TSI
Szabó, J.; Fóris, G.; Keresztes, T.; Varga, Z.; Bakó,
G.; Mezösi, E.; Nagy, E.; Paragh, G.; Leövey, A. (Debrecen)
16:00 - 16:30 Coffee break
Tuesday, September 2nd
Lecture Room 215
15:00 - 16:00 Poster discussion 5: Thyroid Cancer,
Clinical Disturbances of Thyroid Function
Discussion Leader: Bernard M. Goslings, Leiden
106. The APC gene is linked to structurally but not functionally differentiated
thyroid tumours
Williams, G. H.; Thomas, G. A.; Harach, H. R.; Churchward, M.; van Heerden,
J.; Williams, E. D. (Cambridge, Rochester)
107. Sensitivity of the chromatographic determination of endogenous
thyroid hormone synthesis in detection of (micro-) metastases of differentiated
thyroid cancer versus determination of thyroglobulin and 131I whole-body
scanning
Homayounfar, T.; Behr, T. M.; Gratz, S.; Herrmann, A.; Kruck, E.; van Ophemert,
S.; Schreivogel, I.; Hüfner, M.; Becker, W. (Göttingen)
108. Use of recombinant human TSH in a patient with metastatic follicular
thyroid carcinoma and secondary hypothyroidism
Luster, M.; Reinhardt, W.; Körber, C.; Rendl, J.; Mann, K.; Reiners,
C. (Würzburg, Essen)
109. Effect of suppressive treatment with thyroid hormones on bone mass
(QCT study) in differentiated thyroid cancer after surgery
Gãleºanu, C. (Iasi)
110. Comparison among different 131I activities for ablation of post-
surgical thyroid residues
Angelini, F.; Capezzone, M.; Ceccarelli, C.; Lippi, F. (Pisa)
111. Contribution of high-resolution ultrasonography in the early diagnosis
of thyroid malignancy
Kovatcheva, R.; Kanev, N.; Ivanova, R. S.; Ivanova, R. B.; Dashev, G. (Sofia)
112. Evaluation of technetium-99m-MIBI scintigraphy in metastatic differentiated
thyroid carcinoma
Kasagi, K.; Miyamoto, S.; Alam, M. S.; Misaki, T.; Konishi, J. (Kyoto)
113. Sporadic thyroid medullary microcarcinoma: a retrospective study
in 80 patients
Beressi, N.; Campos, J. M.; Franc, B.;Niccoli, P.; Dumontier, D.; Boneu,
A.; Baldet, L.; Murat, A.; Saint André, J. P.; Le Bodic, F.; Maes,
B.; Modigliani, E. (Bobigny)
114. Outcome of insular thyroid carcinomas
Giuffrida, D.; Pellegriti, G.; Iurato, M. P.; La Rosa, G. L. Regalbuto,
C.; Belfiore, A. (Catania)
115. Cystic thyroid carcinoma: the incidence and diagnostic method
Kobayashi, K.; Yokozawa, T.; Fukata, S.; Hirai, K.; Matsuzuka, F.; Kuma,
F.; Miyauchi, A. (Kobe, Kagawa)
16:00 - 16:30 Coffee break
Tuesday, September 2nd
Lecture Room 116
16:30 - 17:45 Poster discussion 6: Autoimmunity
Discussion Leader: Paolo Vitti, Tirrenia-Pisa
116. Anti HSP72 antibodies are present in Graves' disease (GD) patients
and in smoking controls
van Pareren, Y. K.; Prummel, M. F. (Amsterdam)
117. Soluble InterCellular Adhesion Molecule-1 (sICAM-1) is a marker
of autoimmunity in Graves' disease
Sonnet, E.; Maugendre, D.; Gibassier, J.; Allannic, H.; Massart, C. (Rennes)
118. Expression of membrane and soluble intercellular adhesion molecule-1
(ICAM-1) in Graves' disease
Massart, C.; Gibassier, J.; Maugendre, D.; Genetet, N.; Leclech, G.; Sonnet,
E. (Rennes)
119. Intrathyroidal T-lymphocytes in Graves' disease
Manfras, B. J.; Gerngroß, H.; Becker, H. P.; Lotspeich, E.; Böhm,
B. O. (Ulm)
120. The increased secretion of serum soluble interleukin-6 receptor
in hyperthyroid Graves' patients with active ophthalmopathy is not related
to the detection of thyroid autoantibodies
Salvi, M.; Girasole, G.; Pedrazzoni, M.; Giuliani, N.; Minelli, R.; Roti,
E. (Parma)
121. Serum levels of interleukin-6 (IL-6) are elevated in patients with
active thyroid associated ophthalmopathy (TAO)
Moncayo, R.; Herold, M.; Riccabona, G. (Innsbruck)
122. Inhibitory effect of pentoxifylline on HLA-DR expression and glycosaminoglycan
synthesis of retrobulbar fibroblasts induced by interleukin-1, tumor necrosis
alpha and interferon gamma
Balázs; C.; Kiss, E.; Farid, N. R. (Debrecen; Chatham)
123. Retinoic acid (RA) receptor expession and effects of RA on morphology,
apoptosis and cAMP levels in cultured orbital fibroblasts from patients
with thyroid associated ophthalmopathy
Pasquali, D.; Ventre, I.; Valente, A.; Vassallo, P.; Bonavolontà,
G.; Bellastella, A.; Sinisi, A. A. (Naples)
124. Somatostatin receptor scintigraphy before and after treatment with
somatostatin analogues in patients with thyroid eye disease
Krassas, G. E.; Doumas, A.; Kaltsas, T.; Pontikides, N. (Thessaloniki)
125. T-cell repertoire against a single pathogenic thyroglobulin epitope
utilizes multiple Vb genes
Rao, V. P.; Russell, R.; Carayanniotis; G. (St. John"s)
126. Graves" disease after percutaneous ethanol injection for the
treatment of hyperfunctioning thyroid adenoma
Caraccio; N.; Monzani, F.; Lippolis, P. V.; Casolaro, A.; Tsiknaki, E.;
Goletti, O. (Pisa)
17:45 - 18:30 General Assembly
19:45 Banquet, Künstlerhaus
Tuesday, September 2nd
Lecture Room 117
16:30 - 17:45 Poster discussion 7: Clinical Disturbances
of Thyroid Function
Discussion Leader:Michael J. Cullen, Dublin
127. Thyroid hormone metabolism in human placenta in mild to moderate
iodine deficiency
Wroclawska, M.; Bednarczuk, T.; Radomski, R.; Capala-Szczurko, I.; Kondracka,
A.; Nauman, A.; Nauman, J. (Warsaw)
128. Muscle metabolism disorder in subclinical hypothyroidism
Monzani, F.; Caraccio, N.; Siciliano, G.; Casolaro, A.; Manca, L.; Tsiknaki,
E.; Ferrannini, E. (Pisa)
129. Iodine excess does not potentiate the effect of recombinant Interferon
a (rIFNa) on the development of thyroid function abnormalities in patients
with HCV hepatitis
Minelli, R.; Schianchi, C.; Valli, A.; Fiaccadori, F.; Ugolotti, G.; Pedrazzoni,
M.; Salvi, M.; Roti, E. (Parma)
130. Association of hyperthyroidism and primary hyperparathyroidism
Klemm, T.; Lamesch, P. (Leipzig)
131. Early events in the treatment of hyperthyroidism due to Graves'
disease (GD) using methimazole (MMI) combined with L-thyroxine in Belgium
Glinoer, D.; De Nayer, P.; Bex, M.; Imschoot, J. (Brussels)
132. Lack of increased frequency of thyroid dysfunction in myasthenia
gravis
Weissel, M.; Mayr, N. (Vienna)
133. Is it useful to treat patients with subclinical hyperthyroidism?
Wemeau, J. L.; Waterlot, C.; Devemy, F.; Bauters, C.; Coviaux, R.; Racadot,
A.; D"Herbomez, M. (Lille)
134. Acute effects of ovulation induction for in-vitro-fertilisation
(IVF) on thyroid function
Muller, A. F.; Mantel, M. J.; Verhoeff, A.; Berghout, A. (Rotterdam)
17:45 - 18:30 General Assembly
19:45 Banquet, Künstlerhaus
Tuesday, September 2nd
Lecture Room 118
16:30 - 17:45 Poster discussion 8: Thyroid Hormone
Action
Discussion Leader: Alberto Muñoz, Madrid
135. Retinoic acid receptor isoform b1 in human renal clear cell cancer:
similarity of expression with triiodothyronine receptor isoform b1
Pietrzykowski, A.; Nauman, A.; Nauman, J.; Dutkiewicz, S.; Witeska, A.
(Warsaw)
136. Triiodothyronine (T3) increases insulin-like growth factor binding
protein-4 (IGFBP-4) expression in rat kidney
Massajoli, M.; Bottazzi, C.; Demori, I.; Voci, A. (Genova)
137. Triiodothyronine receptor in human renal clear cell cancer: overexpression
of b1 isoform in tumor cells
Nauman, A.; Nauman, J.; Pietrzykowski, A.; Luczak, J.; TaÒski, Z.;
Dutkiewicz, S.; Witeska, A. (Warsaw)
138. Naturally occurring mutations in the human b1-thyroid hormone receptor
may induce a change from noncompetitive to competitive inhibition of T3
binding by desethylamiodarone
van Beeren, H. C.; Bakker, O.; Wiersinga, W. M. (Amsterdam)
139. Familial resistance to thyroid hormone (RTH) without triiodothyronine-receptor
b1 (TRb1) anomaly - Pathogenic hypothesis
Vlaeminck, V.; Margotat, A.; Torresani, J.; D"Herbomez, M.; Decoulx,
M.; Wemeau, J. L. (Lille)
140. Discovery of a novel de novo mutation at codon 251 of exon 8 of
thyroid hormone receptor b1 in a kindred with resistance to thyroid hormone
Macchia, E.; Agostini, M.; Sarkissian, G.; Giorgilli, G.; Canale, D.; Licitra,
R.; Franchi, R.; Margotat, A.; Torresani, J.; Pinchera, A. (Marseille)
141. Functional cooperation of thyroid hormone receptor b1 with the
tumor suppressor p53
Yu, C.-L.; Cheng, S.-Y.; (Bethesda)
142. Amiodarone induces a hypothyroid-like increase in thyroid hormone
receptor a2 isoform gene expression in rat liver
Bakker, O.; Meijssen, S.; Hudig, F. (Amsterdam)
17:45 - 18:30 General Assembly
19:45 Banquet, Künstlerhaus
Tuesday, September 2nd
Lecture Room 214
16:30 - 17:45 Poster discussion 9: Thyroglobulin
/ Thyroid Peroxidase
Discussion Leader: Jan J. M. De Vijlder, Amsterdam
143. Thyroid peroxidase (TPO) and iodination in human breast tissue
Kilbane, M. T.; Tuite, A. M.; Shering, S. G.; Smith, D. F.; McDermott,
E. W. M.; O"Higgins, N. J.; Smyth, P. P. A. (Dublin)
144. In vivo occupancy of thyroid-specific transcription factors and
NF-1/CTF binding sites in the regulation of the rat thyroperoxidase gene
Ortiz, L.; Cato, A. C. B.; Santisteban, P. (Madrid)
145. Synthesis, folding and intracellular trafficking of human thyroperoxidase
expressed in CHO cells. Role of N-glycans
Fayadat, L.; Niccoli, P.; Lanet, J.; Franc, J. L. (Marseille)
146. IgGk anti-thyroid peroxidase antibodies in Hashimoto's thyroiditis:
epitope mapping analysis
Czarnocka, B.; Janota-Bzowski, M.; McIntosh, R. S.; Suhail-Asghar, M.;
Watson, P. F.; Kemp, E. H.; Weetman, A. P. (Warsaw, Sheffield)
147. The incidence of anti TPO antibodies and of hyperthyroidism secondary
to multinodular goiter or Graves" disease in different population
groups in two areas: one with normal iodine intake and the other with moderate
iodine deficiency
Simescu, M.; Varciu, M.; Nicolesu, E.; Avram, A.; Voiculescu, G. (Bucharest,
Brasov, Pitesti, Vienna)
148. In old age the majority of thyroid peroxidase autoantibodies are
directed to a single TPO domain irrespectively of the thyroid function
and iodine intake
Szabolcs, I.; Czarnocka, B.; Pastuszko, D.; Feldkamp, J.; Dohán,
O.; Podoba, J.; Wenzel, B. (Budapest, Warsaw, Düsseldorf, Bratislava,
Lübeck)
149. Influence of the enzyme activity of thyroid peroxidase by autoantibodies
in primary thyroid cell cultures
Zahn, C.; Braunschweig, I.; Beyer, C.; Müller, G. (Halle - Wittenberg)
17:45 - 18:30 General Assembly
19:45 Banquet, Künstlerhaus
Tuesday, September 2nd
Lecture Room 215
16:30 - 17:45 Poster discussion 10: Thyroid Cancer,
Thyroid Cell Biology
Discussion Leader: Sir Dillwyn Williams, Cambridge
150. Expression of Transforming Growth Factor-b (TGF-b) Receptors (TbR)
and smad proteins in thyroid carcinoma cell lines: Lack of responsiveness
to TGF-b in a cell line with functional Type I and Type II TbR"s Heldin,
N.-E.; Bergenstråhle, A.; Nakao, A.; Westermark, B.; ten Dijke, P.
(Uppsala)
151. Regulation of the CD97 protein in a human follicular thyroid carcinoma
cell line
Hoang-Vu, C.; Aust, G.; Laue, S.; Schwarz, I.; Lotz, O.; Sutter, T.; Goretzki,
P.; Brabant, G.; Dralle, H. (Halle - Wittenberg, Leipzig, Düsseldorf,
Hannover)
152. VEGFc expression in various human thyroid diseases Karamysheva,
A.; Bronstein, M.; Shushanov, S.; Adelaide, J.; Shatalova, L.; Stavrovskaya,
A.; Birnbaum, D. (Moscow, Marseille)
153. Laminin receptors in differentiated thyroid tumors
Montuori, N.; Müller, F.; De Riu, S.; Fenzi, G. F.; Rossi, G.; Vitale,
M. (Naples)
154. Constitutive activation of the tyrosine kinase receptor met in
human anaplastic thyroid carcinoma cells in culture
Bergström; D.; Diaz de Ståhl, T.; Hermansson, A.; Westermark,
B.; Heldin, N.-E. (Uppsala)
155. Retained epithelial properties and high expression of ZO-1, E-cadherin,
catenins and desmoglein in the established anaplastic thyroid carcinoma
cell line KAT4
Husmark, J.; Nilsson, M. (Göteborg)
156. ß1-Integrin Expression in Papillary Thyroid Carcinoma
Ensinger, C.; Bacher-Stier, C.; Moncayo, R.; Riccabona, G.; Mikuz, G.;
Obrist, P. (Innsbruck)
157. DNA hypermethylation is involved in altered expression of cell
adhesion molecules of the E-cadherin/catenin system in human thyroid carcinoma
cells
Pötter, E.; Oster, H.; Mayr, B.; Brabant, G. (Hannover)
158. Integrin binding to insoluble fibronectin prevents apoptosis of
thyroid cells
Vitale, M.; Di Matola, T.; De Riu, S.; Muller, F.; Salzano, S.; Fenzi,
G. F.; Rossi, G. (Naples)
159. Interleukin-1b suppresses apoptosis in human thyroid cells
Rasmussen, Å. K.; Hartoft-Nielsen, M.-L.; Stenvang, J. P.; Ravnsbæk,
J.; Buschard, K.; Feldt-Rasmussen, U. (Copenhagen)
160. Involvement of apoptosis and fas system on goiter formation and
involution in rat thyroid
Tamura, M.; Kimura, H.; Koji, T.; Tominaga, T.; Fujiyama, K.; Kiriyama,
T.; Yokoyama, N.; Yoshimura, T.; Nakane, P. K.; Nagataki, S. (Nagasaki)
161. Extracellular matrix components in native and cultured rat thyroid
tissue and in FRTL-5 cells
Bürgi-Saville, M. E.; Reut, B.; Kämpf, J.; Simon, F.; Peter,
H. J.; Paulsson, M.; Gerber, H. A.; Bürgi, U. (Bern)
17:45 - 18:30 General Assembly
19:45 Banquet, Künstlerhaus
Wednesday, September 3rd
"Auditorium Maximum"
08:15 - 10:15 Oral Session 12: Topic Highlights
II
Chair: Roland Gärtner, Munich
Co-chair: Hemmo A. Drexhage, Rotterdam
08:15 162. Characterization of the rat thyroid iodide transporter using
antipeptide antibodies: Relationship between its expression and functional
activity
Paire, A.; Bernier-Valentin, F.; Selmi-Ruby, S.; Rousset, B. (Lyon)
08:35 163. Constitutively activating TSH receptor mutations are predominant
in clonal toxic thyroid nodules
Krohn, K.; Führer, D.; Holzapfel, H.-P. (Leipzig)
08:55 164. Cyclin D3 integrates the cAMP-dependent mitogenic pathway
of TSH and the permissive pathway of insulin in dog thyrocytes
Depoortere, F.; Van Keymeulen, A.; Lukas, J.; Bartek, J.; Dremier, S.;
Roger, P. P. (Brussels, Copenhagen)
09:15 165. A transgenic mouse model for resistance to thyroid hormone:
Implications for brain and behavioral research
Lazar, J.; Sui-Foh, Y.; Detolla, L. J.; Hauser, P. (Baltimore)
09:35 166. A higher responsiveness to T3 is conferred by a V444A mutation
in c-ERB A b detected in a patient with symptoms of hypersensitivity to
thyroid hormones
Sarkissian, G.; Margotat, A.; Dace, A.; Lenoir, C.; Malezet, C.; Baldet,
L.; Bringer, J.; Jaffiol, C.; Torresani, J. (Marseille, Montpellier)
09:55 167. A quantitative MRI study of brain structures in subjects
with resistance to thyroid hormone (RTH)
Hauser, P.; Schultheiss, M. B.; Jordan, P.; Du Busc, E.; Laney, C.; Lazar,
J. (Baltimore)
Wednesday, September 3rd
"Auditorium Maximum"
10:15 - 10:45
Lissitzky Prize
ETA Organon M. Pierre König Poster Award
10:45 - 11:15 Coffee break
Wednesday, September 3rd
"Auditorium Maximum"
11:15 - 12:45 Oral Session 13: Clinical Disturbances
of Thyroid Function
Chair: John H. Lazarus, Cardiff
Co-chair: Georg Hennemann, Rotterdam
11:15 168. Identification of a mutation in the PAX-8 gene in a patient
with thyroid ectopy
Macchia, P. E.; Lapi, P.; Chiovato, L.; Busslinger, M.; Fenzi, G. F.; Di
Lauro, R. (Naples, Pisa, Vienna)
11:30 169. Analysis of human sodium iodide symporter gene expression
in extrathyroidal tissues
Spitzweg, C.; Joba, W.; Heufelder, A. E. (Munich)
11:45 170. Increased expression of the NA+ / I- symporter in cultured
human thyroid cells by thyrotropin and in Graves' thyroid tissues
Saito, T.; Endo, T.; Kawaguchi, A.; Ikeda, M.; Nakazato, M.; Kogai, T.;
Onaya, T. (Yamanashi - Tamaho)
12:00 171. Effects of thiocyanate overload in addition to combined selenium
and iodine deficiencies on thyroid necrosis. Possible implications in the
aetiology of myxoedematous cretinism
Contempré, B.; Geets, X.; Dumont, J. E.; Morreale de Escobar, G.;
Denef, J.-F.; Many, M.-C. (Brussels, Madrid)
12:15 172. TPO antibodies and improved outcome in breast cancer
Smyth, P. P. A.; Shering, S. G.; Kilbane, M.; McDermott, E. W. M.; Smith,
D. F.; O"Higgins, N. J. (Dublin)
12:30 173. Expression of thyroxine-binding globulin-SER23THR in xenopus
oocytes confirms its isolated binding defect
Astner, S. T.; Treske, B.; Gunn, S. K.; Refetoff, S.; Janssen, O. E. (Munich,
Houston, Chicago)
12:45 - 14:30 Lunch and Poster display
Wednesday, September 3rd
"Kleine Aula" - Lecture Room 209
13:15 - 14:30 Clinical Symposium: "Measurement
of TSH-receptor antibodies in pregnancy?"
Chair: Peter Laurberg, Aalborg
Introduction
P. Laurberg, Aalborg
Basic studies
J. J. Orgiazzi, Lyon
Clinical studies
B. Nygaard, Copenhagen
Epidemiology / cost benefit considerations
D. Glinoer, Brussels
Concluding remarks
M. Grußendorf, Stuttgart
Wednesday, September 3rd
Lecture Room 116
14:30 - 16:00 Poster discussion 11: Autoimmunity
Discussion Leader: J. Paul S. Banga, London
174. Clinical role of anti-TGPO in autoimmune thyroid disease - a useful
thyroid autoantibody?
Zöphel, K.; Franke, W.-G.; Wunderlich, G.; Kühne, A.; Kropp,
J.; Augustin, K. (Dresden)
175. Biochemical characteristics of anti-TGPO antibody binding properties:
Evidence for two different binding sites to thyroglobulin and thyroperoxidase
Kornfeld, S.; Talke, M.; Ruf, J.; Carayon, P. (Berlin, Marseille)
176. Thyrotropin receptor stimulating (TSAb) and stimulation blocking
(TSBAb) antibody activities in patients with autoimmune thyroid diseases
(AITD)
Wallaschofski, H.; Meyer, A.; Tuschy, U.; Paschke, R. (Leipzig, Erfurt)
177. The presence of anti-TSH antibodies in the euthyroid state of Graves'
disease
Molnár, I.; Szabó, E.; Balázs, C. (Debrecen)
178. Use of proteolytic peptides from native human TPO to map conformational
B-cell epitopes involved in autoimmune thyroid diseases
Estienne, V.; Duthoit, C.; Vinet, L.; Durand-Gorde, J. M.; Ruf, J. (Marseille)
179. Is the TPO-antibody level in Graves' disease (GD) a useful index
to predict recurrence?
Geling, M.; Luster, M.; Rendl, J.; Reiners, C. (Würzburg)
180. Anti-eye-muscle antibodies in patients with Thyroid Associated
Ophthalmopathy (TAO)
Dakovska, L.; Kovatcheva, R.; Todorova, S.; Lozanov, B.; Ivanova, R.; Atanassova,
I.; Aslanova, N. (Sofia)
181. Circulating anti-cardiolipin antibodies in autoimmune thyroid disease
Marino, M.; Latrofa, F.; Barbesino, G.; Mariotti, S. (Pisa, Cagliari)
182. Diagnostic value of a new anti-TG assay in various thyroid diseases
Grüning, T.; Zöphel, K.; Wunderlich, G.; Franke, W.-G.; Kühne,
A.; Kropp, J. (Dresden)
183. Administration of human immunoglobulins (hIgs) may inhibit thyroid
function in neonatal thyrotoxicosis
Péter, F.; Kalmár, Á.; Beregszászi, M.; Muzsnai,
Á. (Budapest)
184. The development of hypothyroidism caused by blocking type TRAb
in an euthyroid patient with Graves" disease after 131I treatment
and chronic hepatitis C treated with interferon-a
Fukazawa, H.; Yoshida, K.; Shimizu, K.; Kojima, S.; Abe, K. (Sendai)
16:00 Closing ceremony
Wednesday, September 3rd
Lecture Room 117
14:30 - 16:00 Poster discussion 12: Clinical Disturbances
of Thyroid Function
Discussion Leader: Mark F. Prummel, Amsterdam
185. Thyroxine supplementation to infants <30 weeks' gestation may
reduce mortality in the absence of antenatal steroids
van Wassenaer, A. G.; Kok, J. H. (Amsterdam)
186. Measuring quality of life in Graves' ophthalmopathy (GO) patients
Gerding, M. N.; Terwee, C. B.; Dekker, F. W.; Koornneef, L. (Amsterdam)
187. Glycosaminoglycan urine excretion as a marker of the acute phase
of Graves' ophthalmopathy
Daroszewski, J.; Pelczar, E.; GrabiÒski, M.; Oficjalska, J.; Gamian,
A.; Rybka, J.; Wielgus, W.; Bolanowski, M.; Malachowski, K. (Warsaw)
188. Significance of heterogeneity on MRI-T2 of extraocular muscles
in Graves" ophthalmopathy; prediction of the effect of medical treatments
on diplopia
Yokoyama, N.; Tamura, M.; Tominaga, T.; Kimura, H.; Ashizawa, K.; Kiriyama,
T. (Nagasaki)
189. Somatostatin receptor expression in retroorbital lymphocytes and
fibroblasts from patients with Graves' ophthalmopathy
Sinisi, A. A.; Pasquali, D.; Vassallo, P.; Ventre, I.; Nicchio, M. R.;
Bonavolontà, G.; Bellastella, A. (Naples)
190. Octreoscan in Graves' disease (GD): Predictive value and follow-up
during therapy
Kahaly, G.; Görges, R.; Diaz, M.; Hommel, G.; Beyer, J.; Bockisch,
A. (Mainz)
191. Treatment of Graves' orbitopathy by intravenous immunoglobulin
administration
Rodionova, T.; Semenova, T.; Ledvanov, M. (Saratov)
192. The thyroid autoimmune and subtle function disturbances in euthyroid
patients with thyroid associated ophthalmopathy
Lozanov, B.; Atanassova, I.; Kirilov, G.; Kovatcheva, R.; Barliev, G. (Sofia)
193. Thyroid function and the course of thyroid-associated orbitopathy
in the treatment of Graves' disease by different doses of methimazole
Rodionova, T. (Saratov)
194. Two types of post-partum thyroid disease: An autoimmune (AI) and
a non-autoimmune form
Kuijpens, J. L.; Vader, H. L.; de Haan-Meulman, M.; Pop, V. J.; Wiersinga,
W. M.; Drexhage, H. A. (Rotterdam, Amsterdam)
195. Serum interleukin-6 (IL-6) levels are not increased in post-partum
thyroiditis (PPT)
Parkes, A. B.; Bartalena, L.; Brogioni, S.; Grasso, L.; Tanda, M. L.; Cecconi,
E.; Bogazzi, F.; Lazarus, J. H.; Martino, E. (Cardiff, Pisa)
16:00 Closing ceremony
Wednesday, September 3rd
Lecture Room 118
14:30 - 16:00 Poster discussion 13: Clinical Disturbances
of Thyroid Function
Discussion Leader: Jens Faber, Frederiksberg
196. Study of the 10th exon (1018-1410 bp) of human TSH-receptor gene
in Graves' disease
Kaczur, V.; Takács, M.; Falus, A.; Krajczár, G.; Nagy, Z.;
Berencsi, G.; Balázs, C. (Debrecen, Budapest)
197. Regulation of TTF-1 function by TSH and IGF-I is mediated by a
precise control of its phosphorylation
Medina, D. L.; Velasco, J. A.; Santisteban, P. (Madrid)
198. Prognostic value of elevated TSH levels, thyroid antibodies and
impaired thyroid reserve in subclinical hypothyroidism: Prospective follow-up
up to 16 years and its natural course
Huber, G.; Mitrache, C.; Guglielmetti, M.; Huber, P.; Staub, J.-J. (Basel)
199. Nocturnal TSH secretion before and after CPAP-treatment in patients
with severe sleep apnea syndrome
Reinhardt; W.; Semenczuk, A.; Jockenhövel, F.; Wessendorf, T.; Brabant,
G.; Konietzko, N.; Teschler, H.; Mann, K. (Essen, Hannover)
200. The pituitary-thyroid feedback control: Stability and oscillations
in a new nonlinear model
Dietrich, J. W.; Mitzdorf, U.; Weitkunat, R.; Pickardt, C. R. (Munich)
201. Diagnostic work up of a hypophyseal adenoma associated with empty
sella
Berger, F.; Meyer, G.; Pfluger, T.; Tatsch, K.; Hahn, K. (Munich)
202. Chemiluminescence assay for the determination of free T4 with the
Liaison® analyzer system
Markowitz, G.; Gehrke, W. (Dietzenbach)
203. Improved protection against heterophilic antibody interferences
in a DELFIA FT3 Assay when using a three-step design
Sahlberg, H.; Männistö, L.; Jämiä, M.; Ståhlberg,
T. (Turku)
204. Liaison® T4, a fully automated chemiluminescent immunoassay
based on magnetic particles
Mack, M.; Markowitz, G.; Gehrke, W. (Dietzenbach)
205. Liaison® FT3, a fully automated chemiluminescent immunoassay
based on magnetic particles
Markowitz, G.; Drahovsky, M.; Weiß, A. (Dietzenbach)
206. Screening for new thyroid dysfunction in a primary care unit using
a third-generation TSH assay
Meier, C.; Roth, C. B.; Kunz, M.; Guglielmetti, M.; Martina, B.; Huber,
P.; Staub, J. J. (Basel)
207. Liaison® TSH: Development of a chemiluminescent 3rd generation
TSH assay for the use on the fully automated Liaison® random access
analyzer
Sander, P. H.; Mack, M.; Deissler, C.; Oed, M. (Dietzenbach)
208. A new method for diagnosing subclinical hyperthyroidism in patients
with suppressed TSH levels
Chernova, T.; Gerasimov, G.; Goncharov, N.; Ehrenkranz, J. (Moscow, Cedar
Knolls)
16:00 Closing ceremony
Wednesday, September 3rd
Lecture Room 214
14:30 - 16:00 Poster discussion 14: TSH and TSH
Receptors, Thyroid Cancer
Discussion Leader: Michael Derwahl, Bochum
209. Thyrotropin receptor mutations in hyperfunctioning thyroid adenomas
Nogueira, C. R.; Santos, C. L. S.; Kopp, P.; Medeiros-Neto, G. (São
Paulo)
210. Structural analysis of the TSH-receptor in congenital hypothyroidism
due to thyroid hypoplasia
Medeiros-Neto, G.; Kopp, P.; Rodrigues, J.; Lando, V. S.; Nogueira, C.
R. (São Paulo)
211. Mutational analysis of the TSH-R gene in differentiated thyroid
carcinoma
Cetani, F.; Barsacchi, R.; Giulianetti, B.; Miccoli, P.; Basolo, F. (Pisa)
212. Thyroid expression of an A2-adenosine receptor induces iodine accumulation
in light lysosomes
van den Hove, M. F.; Legssyer, R.; Couvreur, M.; Gerard, A. C.; Coppee,
F.; Ledent, C. (Brussels)
213. Cause of childhood thyroid cancer after Chernobyl accident
Nagataki, S.; Ashizawa, K.; Yamashita, S.; Shibata, Y. (Nagasaki)
214. Maternal hypothyroidism and the effect of small doses of 131I on
the development of the rat fetus
Lyzogubov, V. V.; Kornilovska, I. N.; Usenko, V. S.; Lepekhin, E. A.; Witt,
M. (Dnepropetrovsk, Dresden)
215. DIDS (4,4"-diisothiocyanatostilbene-2-2"-disulfonic acid)
increases iodide trapping, free-iodide accumulation, inhibits thyroperoxidase
and antagonizes the TSH-induced efflux in primary cultured porcine thyroid
cells
Fayet, G.; Amphoux-Fazekas, T.; Hovsépian, S.; Samih, N.; Aouani,
A.; Beauwens, R. (Marseille, Brussels)
216. Iodide-induced apoptosis in the FRTL-5 thyroid cell line reflects
changes in the autocrine availability of transforming growth factor-b1
(TGF-b1)
Bellairs, H. J.; Morris, I. D.; Bidey, S. P. (Manchester)
217. Apoptosis in porcine thyroid follicles in vitro after treatment
with iodine and d-iodolactone
Sachse, A.; Burzler, C.; Fröschl, H.; Schopohl, D.; Gärtner,
R. (Munich)
218. Effect of 72-kD heat shock protein (hsp-72) on iodine transport
into FRTL-5 cell - could it be a piece of the autoimmune thyroid disease
puzzle?
Alam, M. S.; Misaki, T.; Kasagi, K.; Iida, Y.; Miyamoto, S.; Konishi, J.
(Kyoto)
219. Nodular goiter in pregnancy in an iodine deficient region: a retrospective
study
Lo Presti, V. P.; Finocchiaro, M. D.; Violi, M.; Moleti, M.; Castagna,
M. G.; Mattina, F.; Vermiglio, F.; Trimarchi, F. (Messina)
220. Cytological and histopathological evaluation of thyroid neoplasms
in iodine deficient area; comparative study of 862 operated patients
SlowiÒska-Klencka, D.; Sporny, S.; Klencki, M.; LewiÒski,
A. (Lódz)
221. Thyroid nodules in elderly population: Longitudinal study
Mickuviene, N.; KazanaviËius, G. (Kaunas)
222. Intrathyroid iodine concentration in thyroid nodules
Troshina, K.; Tomashevsky, I.; Gerasimov, G.; Bronstein, M.; Alexandrova,
G.; Gerasimov, V.; Figge, J. (Moscow, Albany)
16:00 Closing ceremony
Wednesday, September 3rd
Lecture Room 215
14:30 - 16:00 Poster discussion 15: Thyroid Hormone
Metabolism, Thyroid and the Brain
Discussion Leader: Juan Bernal, Madrid
223. Iodothyronine deiodinase mRNA expression in placenta measured using
semi-quantitative PCR
Stulp, M.; de Vijlder, J. J. M.; Ris-Stalpers, C. (Amsterdam)
224. Differential regulation of the human selenoproteins 5"-deiodinase
and selenoprotein p by proinflammatory cytokines
Dreher, I.; Jakobs, T. C.; Köhrle, J. (Würzburg)
225. Triiodothyroacetic acid (T3AC) - is it an intracellular autocrine
acting form of thyroid hormone?
Beale, E.; Srivastava, P.; Liang, H.; LoPresti, J.; Spencer, C.; Nicoloff,
J. (Los Angeles)
226. The effect of 3,5-diiodo-L-thyronine on the respiratory chain in
rat liver mitochondria
Lombardi, A.; Lanni, A.; Moreno, M.; Brand, M. D.; Goglia, F. (Naples,
Salerno, Cambridge)
227. 3,5- and 3,3"-diiodothyronine serum and tissue levels in nonthyroidal
illness
Pinna, G.; Hiedra, L.; Eravci, M.; Meinhold, H.; Baumgartner, A. (Berlin)
228. Serum and mitogens regulate type III 5" deiodinase in proliferating
rat brown preadipocytes. A correlation with mitogenesis
Hernández, A.; García, B.; Obregón, M. J. (Madrid)
229. Cognitive state and selective hormone replacement in hypothyroidism
BuneviËius, R.; KazanaviËius, G. (Kaunas)
230. Short-term iodized salt supply does not correct maternal hypothyroxinemia
in a moderately iodine deficient area
Vermiglio, F.; Lo Presti, V. P.; Castagna, M. G.; Finocchiaro, M. D.; Moleti,
M.; Mattina, F.; Violi, M. A.; Artemisia, A.; Giorgianni, G.; Foti, M.;
Trimarchi, F. (Messina)
231. Short term lipoprotein (a) [Lp(a)] control by thyroid hormones
Klein, M.; Gastin, I.; Aubert, V.; Barbé, F.; Giordano, M.; Guéant,
J.-L.; Weryha, G.; Lecrère, J. F. (Vandoeuvre - Nancy)
16:00 Closing ceremony
SOCIAL PROGRAM
Get together Party
Date: Saturday, August 30th, 1997
Time: 18:00 hrs
Location: "Lichthof" of the LMU
Price: free of charge (only for registered participants and registered
accompanying persons)
All registered participants and accompanying persons are invited to attend
the welcome party which will be held in the main entrance hall ("Lichthof")
of the University of Munich.
Municipal Welcome
Date: Sunday, August 31st, 1997
Reception Time: 19:00 - 21:00 hrs
Location: Old City Hall, "Marienplatz"
Price: free of charge (only for registered participants and registered
accompanying persons)
Christian Ude, the Lord Mayor of the City of Munich and a representative
of the bavarian government welcome our participants and accompanying persons
in the Old City Hall of Munich. It is located at the "Marienplatz",
which can be reached within 15 minutes by walking from the university or
by underground.
Bavarian Excursion
Date: Monday, September 1st, 1997
Location: Lake "Starnberg"
Price: DEM 75,-
Immediately after the scientific sessions, we will leave by bus from the
university for the beautiful lake "Starnberg" near Munich. Upon
arrival there, we will enjoy a boat trip on the lake, and dinner will be
served on the boat. There will also be the opportunity to enjoy local music
and dancing.
Congress Banquet
Date: Tuesday, September 2nd, 1997
Location: "Künstlerhaus"
Price: DEM 100,-
We have the pleasure to invite you to the Congress Banquet in the rooms
of the "Künstlerhaus" which is located near "Stachus",
the main center of Munich. It has been built at the end of the last century
as a convention center for the art community of Munich.
PARTNERS PROGRAM
Meeting point for all tours: Registration desk Main entrance hall of
the university ("Lichthof")
Guided Walking City Tour
Date: Sunday, August 31st, 1997, Tuesday, September 2nd, 1997
Time: 14:30 hrs
Price: free of charge (only for registered participants and registered
accompanying persons)
Munich Sightseeing Tour by bus
Date: Monday, September 1st, 1997
Time: 09:30 hrs
Price: DEM 49,-
Munich the capital of Bavaria, on the "Isar" River, is an industrial
and cultural center, known for its elegant shops, fashionable night clubs,
great breweries, and lively festivals. The old part of the city has a number
of baroque and rococo buildings, mostly built in the first half of the
18th-century by the rulers of Bavaria, who were inspired by Italian models.
In the center of the old city is the "Marienplatz", a well known
square, which is dominated by the city hall, the ornate "Neues Rathaus".
Next to the city hall is the 15th-century "Frauenkirche" (Church
of Our Lady), a massive late Gothic brick cathedral with twin towers. The
city also has a large English garden, with a lake and a Chinese Pagoda.
The baroque "Nymphenburg" Castle is located in an opulently landscaped
park. A large stadium was erected for the 1972 Olympic Games, which were
held in Munich. After a comprehensive survey of the city we will pass the
olympic grounds on our way to the Castle of "Nymphenburg", the
former Summer residence of the Bavarian Kings. Munich is the seat of the
Ludwig Maximilian University, founded in "Ingolstadt" in 1472
by Ludwig IX, duke of Upper and Lower Bavaria, and was transferred to "Landshut"
in 1800 and to Munich in 1826. In addition, Munich has a technical university
(founded in 1868) as well as a dozen further institutions of comparable
status. Berlin is the only German city that has more students than the
110,000 enrolled here in Munich.
Dachau Memorial Site
Date: Monday, September 1st, 1997
Time: 09:30 hrs
Price: DEM 45,-
In Germany, the Nazis established concentration camps almost immediately
after assuming power on January 30th, 1933. A decree in February removed
the constitutional protection against arbitrary arrest. The concentration
camp near Dachau represents one of the most impressive documents of the
cruelty of the Third Reich. The security police had the authority to arrest
anyone and to commit that person to a camp for an indefinite period. The
political police, known as the Gestapo, imposed "protective custody"
on a wide variety of political opponents: Communists, socialists, religious
dissenters and Jews. This Memorial of inhumanity has been preserved as
an everlasting reminder of the cruelties committed during the Third Reich.
Oberammergau Bavarian Alps
Date: Tuesday, September 2nd, 1997
Time:
Price: DEM 120,-
One day bus tour to the famous "Linderhof" Castle built by King
Ludwig II. You will have plenty of opportunity to enjoy the beautiful panorama
of the Bavarian Alps. Oberammergau, on the "Ammer" River, situated
in the Bavarian Alps, is a popular tourist resort and noted wood carving
center. The famous Passion Play, which originated in 1634, is performed
here. It was first presented by the inhabitants in gratitude for the end
of a plague. Except for the years 1870, 1920, and 1940, the play has been
presented every tenth year since 1680 in keeping a vow made by the 17th-
century townspeople. The daylong performances are attended by thousands.
Neue Pinakothek Art Gallery
Date: Wednesday, September 3rd, 1997
Time: 09:00 hrs.
Price: DEM 18,-
Munich"s "Neue Pinakothek", contains an important collection
of 19th-century European art. A guide will show and explain the highlights.
GENERAL INFORMATION
Registration Desk will be open during the congress days from
7:30 to 18:00 hrs. Registration will start an Saturday from 15:00 to 19:00
hrs.
Venue Ludwig-Maximilians-University of Munich Main-Building, Geschwister-Scholl-Platz
1 Tel.: +49 (89) 21 80 30 10 (only during the congress)
Industrial Exhibition is located on the first floor in the East
Aisle next to the poster area (see floor plans). If you wish to receive
more information about the exhibition, please, contact the Congress Bureau.
Badges will be required for admission to all scientific and social
events.
Certificates of Attendance will be issued upon request at the
registration desk.
Insurance
All Participants are reminded to insure against medical expenses, loss
and accidents which may occur during the congress. The Local Organizing
Committee can in no way be held responsible.
Coffee breaks
During the breaks, coffee will be offered in the exhibition area.
Luncheons
Drinks and Lunch-snacks will be offered in the inner court ("Südhof")
of the university. Please note that the registration fee does not include
lunches. Lunch Tickets will be sold at the registration desk during the
opening hours.
Parking Facilities are not available around the conference area.
Please use your hotel garage.
Access
All congress related venues are located in the city centre of Munich.
The city is connected to the Munich Airport by local train (S-Bahn S8)
or shuttle bus (Airport - Main-station) and can be reached within 40 minutes.
Taxi price to the city centre about DEM 90,-.
Munich Airport
Tel.: +49 (89) 97 52 13 13
Public transportation system
Reduced tickets for the public transportation system Transportation
(MVV) will be sold at the registration desk during the Tickets opening
hours. This tickets are valid for the inner city.
Money Exchange
Money can be exchanged at most hotels and at the Central Railway Station.
Banking hours in Munich are from 9:00 to 12:30 and from 14:00 to 16:00
hrs.
Visa
A visum is not generally required for the entry into Germany. However,
participants are advised to check with the relevant authority in their
own country
Climate
Bavaria has a moderate climate: temperature 20° C. The weather
in Munich at that time can be anything between hot to moderate to rainy.
We recommand to bring with you an umbrella and a light raincoat.
PRE AND POST SATELLITE SYMPOSIA
Pre
Thursday August 28th - Saturday August 30th, 1997
TFI / Schilddrüsenliga Deutschland e.V.
3rd Annual
Meeting of the Thyroid Federation International (TFI)
organized by: Prof. P. Pfannenstiel Fax: +49 (6134) 72 91 55
Saturday August 30th, 1997
EORTC - Thyroid Study Group
organized by: Prof. D. Wynford-Thomas Fax: +33 (0)4 91 69 89 53
Post
Thursday September 4th - Friday September 5th, 1997
International Symposium Genetics of Thyroid Disease
organized by: Dr. K. Badenhoop Fax: +49 (69) 63 01 64 05 Prof. J. Köhrle
Fax: +49 (931) 5 65 37
Thursday September 4th - Friday September 5th, 1997
WHO - UNICEF - ICCIDD Regional Meeting: "Towards sustainable elimination
of iodine deficiency disorders in Europe"
organized by: Prof. F. Delange Fax: +32 (2) 6 75 18 98 Email: fdelange@ulb.ac.be
Floorplan Congress Center
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